Charming and historic City Drug Store in Wheeler, Texas, was re-built in 1924 after the original wooden structure burned. The cement block structure served the community as a  "drug store" and "soda shop" for the next fifty years.  In the early 30s the first floor was enlarged for doctors offices and The second story was added to serve as the town's first hospital. In the 40s a new hospital was built and the second floor was converted into apartments. Many couples began married life on the second floor of the City Drug Store.

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In the 50s the apartments were abandoned and the second floor remained unused for the fifty years. The City Drug Store continued in business until 1973. The building was vacated in 1993 and remained empty until new owners bought the building and began remodeling the building for the "City Drug Bed & Breakfast Hotel."

Located in scenic and historic Wheeler County, Texas Wheeler became the county seat in 1907. Wheeler County, organized in 1879, was the first organized county in the Texas Panhandle and had jurisdiction over 26 other counties including Greer County, Texas, now Greer County, Oklahoma. The first County seat was Mobeetie, Texas, which "sprang up" under the protection of Fort Elliot, established in 1875, at the end of the Red River Indian Wars of 1874. Wheeler County was in the center of the Indian Wars and many of the battle sites are within 25 miles of Wheeler.